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LAG3
Rabbit Monoclonal antibody(Mab)
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | P18627 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone Names | 412B5F6 |
| Calculated MW | 57449 Da |
| Gene ID | 3902 |
|---|---|
| Other Names | Lymphocyte activation gene 3 protein, LAG-3, CD223, Secreted lymphocyte activation gene 3 protein, sLAG-3, LAG3 (HGNC:6476), FDC |
| Dilution | IHC-P~~N/A |
| Storage | Maintain refrigerated at 2-8°C |
| Name | LAG3 {ECO:0000303|PubMed:35761082, ECO:0000312|HGNC:HGNC:6476} |
|---|---|
| Function | [Lymphocyte activation gene 3 protein]: Inhibitory receptor on antigen activated T-cells (PubMed:20421648, PubMed:35761082, PubMed:7805750, PubMed:8647185). Delivers inhibitory signals upon binding to ligands, such as MHC class II, its main ligand present at the surface of antigen-presenting cells (APCs), and FGL1, which is secreted by hepatocytes and certain types of tumor cells (PubMed:30580966, PubMed:32920841, PubMed:35761082, PubMed:39671469, PubMed:7589152, PubMed:8647185, PubMed:9159144). Ligand-binding initiates a signaling that inhibits the T-cell receptor (TCR) in the immunological synapse, preventing T-cell activation (PubMed:40101708). Mechanistically, ligand-binding promotes (1) ubiquitination of the KIEELE motif, unleashing the RRFSALE motif from the membrane and (2) leading to the formation of condensates with the TCR component CD3E, thereby disrupting the association between CD3E and LCK and preventing TCR activation (PubMed:40101708, PubMed:40592325). May inhibit antigen- specific T-cell activation in synergy with PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed:20421648, PubMed:7805750, PubMed:8647185). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). |
| Cellular Location | [Lymphocyte activation gene 3 protein]: Cell membrane; Single-pass type I membrane protein. Note=Clusters on the T-cell surface following ligand-binding |
| Tissue Location | Primarily expressed in activated T-cells and a subset of natural killer (NK) cells. |
Research Areas
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Application Protocols
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$ 106.00
Cat# AD80600-010
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